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The dextran sodium sulfate colitis mouse model is widely used in preclinical studies to simulate ulcerative colitis, a type of inflammatory bowel disease (IBD) in humans. By administering dextran sodium sulfate (DSS) to mice, researchers can induce inflammation and epithelial damage in the colon, allowing for the investigation of disease mechanisms and the testing of potential therapeutic agents. This model is particularly valuable in evaluating the efficacy of novel treatments for colitis, offering insights into the inflammatory response, tissue repair, and immune regulation processes that are crucial for developing effective therapies for IBD.