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The mesothelioma PDX model has become an invaluable tool in preclinical cancer research, offering a more accurate representation of human mesothelioma compared to traditional cell line-based models. By implanting patient-derived tumors into immunocompromised mice, researchers can closely mimic the disease's biological complexity and response to therapies. This model provides crucial insights into mesothelioma's behavior, allowing for more precise testing of potential drug candidates and personalized treatment options. Utilizing the mesothelioma PDX model accelerates the development of targeted therapies and offers a promising approach for improving patient outcomes.